Clinical outcomes after small-incision lenticule extraction versus femtosecond laser-assisted LASIK for high myopia: A meta-analysis

Aim To compare postoperative clinical outcomes of high myopia after small-incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK). Methods From March 2018 to July 2020, PubMed, MEDLINE, Embase, the Cochrane Library, several Chinese databases were comprehensively searched. The studies meeting criteria selected included; data extracted by 2 independent authors. outcome parameters analyzed with RevMan 5.3. Results This meta-analysis included twelve involving 766 patients (1400 eyes: 748 receiving SMILE 652 FS-LASIK). Pooled results revealed no significant differences following outcomes: logarithm mean angle resolution (logMAR) uncorrected distance visual acuity (weighted difference (WMD) = -0.01, 95% confidence interval (CI): -0.02 0.00, I 0%, P 0.07 at 1 mo; WMD -0.00, CI: -0.01 0.01, 0.83 3 32%, 0.33 long term), refractive spherical equivalent (WMD -0.03, -0.09 0.03, 13%, 0.30). However, group had significantly better corrected (CDVA) than FS-LASIK -0.04, CI, -0.05 -0.02, P<0.00001). In term, total higher-order aberration -0.09, -0.10 -0.07, 7%, P<0.00001) -0.15, -0.19 -0.11, 29%, lower group; a was also found coma -0.05, -0.06 30%, Conclusion For myopia, both are safe, efficacious predictable. demonstrated advantages over terms CDVA, while induced less FS-LASIK. It remains be seen whether can provide quality FS-LASIK; further comparative focused on necessary.